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  • Title: In vivo abnormal keratinazation in Darier-White's disease as viewed by real-time confocal imaging.
    Author: González S, Rubinstein G, Mordovtseva V, Rajadhyaksha M, Anderson RR.
    Journal: J Cutan Pathol; 1999 Nov; 26(10):504-8. PubMed ID: 10599941.
    Abstract:
    Darier-White's disease is a rare autosomal-dominant disorder of keratinization. The underlying pathology for the clinical presentation is acantholysis, and various types of dyskeratosis and acanthosis. In this study, we utilized a non-invasive optical imaging modality, confocal reflectance microscopy, to identify specific histologic features of Darier-White's disease in vivo. Micrographic findings in the confocal images were corps ronds, suprabasal clefts, acantholytic suprabasal keratinocytes, and villi. Real-time confocal images are illustrative and can be well correlated with known light microscopic phenomena, particularly in the case of keratinization abnormalities in Darier-White's disease.
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