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  • Title: Utility of the monoclonal antibody HIK1083 in the diagnosis of adenoma malignum of the uterine cervix.
    Author: Utsugi K, Hirai Y, Takeshima N, Akiyama F, Sakurai S, Hasumi K.
    Journal: Gynecol Oncol; 1999 Dec; 75(3):345-8. PubMed ID: 10600287.
    Abstract:
    OBJECTIVES: The aim of this study was to qualify a staining technique for the diagnosis of adenoma malignum. METHODS: The gastric mucin expression of adenoma malignum, ordinary endocervical adenocarcinoma, and normal cervical glands was immunohistochemically compared using the monoclonal antibody HIK1083. RESULTS: The three categories were clearly distinguished, with 90% (9/10) of cases with positive adenoma malignum, 30% (3/10) of cases with weakly positive ordinary cervical adenocarcinoma, and no (0/10) cases of positive normal cervical glands. CONCLUSIONS: This preliminary report indicates that the use of HIK1083 is valuable in the diagnosis of adenoma malignum.
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