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  • Title: Disulfide cross-linking of subunits F(1)-gamma and F(0)I-PVP(b) results in asymmetric effects on proton translocation in the mitochondrial ATP synthase.
    Author: Gaballo A, Zanotti F, Raho G, Papa S.
    Journal: FEBS Lett; 1999 Dec 10; 463(1-2):7-11. PubMed ID: 10601627.
    Abstract:
    A study is presented on the effect of diamide-induced disulfide cross-linking of F(1)-gamma and F(0)I-PVP(b) subunits on proton translocation in the mitochondrial ATP synthase. The results show that, upon cross-linking of these subunits, whilst proton translocation from the A side to the B F(1) side is markedly accelerated with decoupling of oxidative phosphorylation, proton translocation in the reverse direction, driven by either ATP hydrolysis or a diffusion potential, is unaffected. These observations reveal further peculiarities of the mechanism of energy transfer in the ATP synthase of coupling membranes.
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