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  • Title: Bioavailability of aciclovir after oral administration of aciclovir and its prodrug valaciclovir to patients with leukopenia after chemotherapy.
    Author: Steingrimsdottir H, Gruber A, Palm C, Grimfors G, Kalin M, Eksborg S.
    Journal: Antimicrob Agents Chemother; 2000 Jan; 44(1):207-9. PubMed ID: 10602752.
    Abstract:
    The median bioavailabilities of aciclovir after administration of aciclovir and its prodrug valaciclovir were 21.5 and 70.1%, respectively, in 12 patients with malignant hematological diseases with leukopenia after chemotherapy. The interindividual variations of the bioavailability were 48.5 and 21.0% after administration of aciclovir and valaciclovir, respectively. Neither the bioavailability nor the interindividual variation of area under the concentration-time curve of oral aciclovir or valaciclovir differed from that reported in healthy volunteers.
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