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  • Title: Preparation and activity of some novel organo-metallic complexes against Helicobacter pylori.
    Author: Nagarajan R, Mehta SI, Naik SR, Fabry W.
    Journal: Arzneimittelforschung; 1999 Nov; 49(11):951-4. PubMed ID: 10604049.
    Abstract:
    Some novel organo-metallic complexes were prepared by complexing the antibiotics erythromycin (CAS 114-07-8), doxycycline (CAS 564-25-0), ciprofloxacin (CAS 85721-33-1) and amoxicillin (CAS 26787-78-0) with bismuth citrate and their antibacterial activity against Helicobacter pylori and other micro-organisms were investigated. Amoxicillin-bismuth citrate had the strongest activity against H. pylori with a lowest minimum inhibitory concentration of 0.007 mg/l. The complexes exhibited moderate activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis. The findings suggest that the activity of these organo-metallic complexes might be specifically directed against H. pylori.
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