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  • Title: [Dosage and cariostatic effect of mutanase in a rat experiment].
    Author: Guggenheim B, Regolati B, Riethe P, Weller HK.
    Journal: Dtsch Zahnarztl Z; 1975 Sep; 30(9):611-3. PubMed ID: 1060554.
    Abstract:
    In caries tests on rats, mutanase (mu-1,3-glucanglucano-hydrolase) was admixed in different quantities to a cariogenic diet. The animals were fed eight times a day with a feeding machine for 25 days. A highly significant inhibition of fissural caries was achieved by concentrations of over 50 MU per gram of diet. As a simultaneous plaque reduction was not observed, the effect of the enzyme appears to be due to reduced adhesion or colonization capacity of streptococcus mutans strains in the fissures.
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