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  • Title: N-terminus of mature heat-labile enterotoxin chain B is critical for its extracellular secretion in Vibrio cholerae.
    Author: Mukhija R, Garg LC.
    Journal: FEBS Lett; 1999 Dec 17; 463(3):336-40. PubMed ID: 10606749.
    Abstract:
    The effects of addition of a few amino acids to the amino- and carboxy-terminal regions of the mature portion of the heat-labile enterotoxin chain B (LTB) of Escherichia coli on protein export, secretion and assembly were investigated. In E. coli, LTB (secretory protein) with or without the extension at the N- or C-terminus accumulated in the periplasmic fraction. For Vibrio cholerae, LTB with the extension at the C-terminus was exported to the periplasm followed by secretion to the extracellular milieu. However, LTB with the N-terminus extension was exported to the periplasm only. Our findings suggest that in the case of V. cholerae, the N-terminus of the mature LTB plays an important role in its secretion to the extracellular milieu.
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