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  • Title: Role of adhesion molecules in chronic allograft rejection.
    Author: Nowaczyk M, Górski A, Durlik M, Wyzgał J, Perkowska-Francka A.
    Journal: Arch Immunol Ther Exp (Warsz); 1999; 47(6):373-5. PubMed ID: 10608294.
    Abstract:
    Endothelial adhesion molecules play an important role in T cell recruitment to an allograft site. Therefore, it could be expected that their blocking may be beneficial for allograft survival. In this report, we show that T cells from patients with chronic rejection have an up-regulated ability to adhere to inflamed endothelium in vitro. Furthermore, this enhanced T cell: endothelial interaction could be blocked by anti-VCAM and anti-E-selectin monoclonal antibodies.
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