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  • Title: Plasma progestagens and oestrogens in fetus and mother in late pregnancy.
    Author: Barnes RJ, Nathanielsz PW, Rossdale PD, Comline RS, Silver M.
    Journal: J Reprod Fertil Suppl; 1975 Oct; (23):617-23. PubMed ID: 1060853.
    Abstract:
    Normal Thoroughbred and catheterized Pony mares and their fetuses were used. Fetal oestrogen and progestagen concentrations in late gestation were much higher than maternal values. A major feature of the umbilical steroid concentrations was a large venous-arterial difference in progestagens and total oestrogens throughout late gestation which may indicate a metabolic cycle in the fetus between progesterone and other steroid metabolites. Metabolites of 20alpha-dihydroprogesterone were present in high concentrations in maternal and fetal plasma. In Thoroughbreds, and to a lesser extent in Pony mares, plasma progestagens rose towards parturition while total plasma oestrogen fell. The only oestrogen which showed a rise in concentration near term was oestradiol-17beta. In one Pony mare and fetus, fetal plasma progestagen fell 24 to 36 hr before parturition when maternal peripheral progestagen concentrations remained high.
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