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  • Title: alpha(1L)-adrenoceptors mediate noradrenaline-induced contractions of the guinea-pig prostate stroma.
    Author: Pennefather JN, Lau WA, Chin C, Story ME, Ventura S.
    Journal: Eur J Pharmacol; 1999 Nov 12; 384(1):25-30. PubMed ID: 10611415.
    Abstract:
    The alpha(1)-adrenoceptor subtype mediating noradrenaline-induced contractions of the guinea-pig isolated prostatic smooth muscle was investigated. Noradrenaline produced concentration-dependent contractions of the tissue with a mean pD(2) value of 5.26+/-0.03 (n=20). These contractions were antagonised by prazosin, 2-(2, 6-dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride (WB-4101), N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride (RS-17053) and (R)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]-2-methylethyl]-2- methoxybenzensulfonamide methanesulphonate hydrate (tamsulosin). Mean pA(2) or apparent pK(B) estimates for the antagonism of noradrenaline were 8.15+/-0.05 for prazosin; 8.83+/-0.11 for WB-4101, 7.18+/-0.14 for RS-17053 and 10.11+/-0.12 for tamsulosin. The relatively low estimates of the apparent dissociation constant for all antagonists except tamsulosin indicate that an alpha(1L)-adrenoceptor mediates noradrenaline-induced prostatic smooth muscle contraction in the guinea-pig prostate gland.
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