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  • Title: [Role of 99mTC-Sestamibi in the diagnosis of breast cancer. Report on 100 cases].
    Author: Fliquete Peris MV, Giménez Climent J, Vázquez Forner C, Más Arcas C, Vázquez Albaladejo C.
    Journal: Rev Esp Med Nucl; 1999 Dec; 18(6):436-41. PubMed ID: 10611570.
    Abstract:
    OBJECTIVE: To evaluate the usefulness of the isotopic mammography with 99mTc-MIBI in the diagnosis of tumoral pathology of the mammary gland. METHODS: One hundred women with clinical/radiological suspicion of malignant pathology in the breast and/or lymph nodes were studied. The isotopic technique consisted of administration 740MBq 99mTc-MIBI, i.v., obtaining AP and prone lateral views. RESULTS: The overall sensitivity and specificity for the scintimammography in tumoral detection was 90% and 86% respectively. The sensitivity was 60% in nonpalpable lesions. The scintimammography had a 40% sensitivity and 98% specificity in lymph node detection. CONCLUSION: The complementary use of scintimammography can improve the sensitivity for the detection of breast carcinoma. The diagnostic accuracy of 99mTc-MIBI depends on the tumor size and histopathological characteristics. The 99mTc-MIBI can potentially determine the presence of recurrent breast cancer and multicentric disease.
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