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  • Title: Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors.
    Author: Ono S, Kuwahara S, Takeuchi M, Sakashita H, Naito Y, Kondo T.
    Journal: Bioorg Med Chem Lett; 1999 Dec 06; 9(23):3285-90. PubMed ID: 10612586.
    Abstract:
    We report the syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Among the compounds we evaluated, 1,5-Bis[4-(5-amidinobenzofuran-2-ylcarbonyl)piperazinylca rbonylmethoxy]cyclooctane 26 (AY0068) was found to be a selective and potent non-peptide inhibitor. 26 was effective in PCA reaction in rats without showing antihistaminic activity.
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