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  • Title: [Induction of abortion in the second trimester by prostaglandin vagitories].
    Author: Heimstad RK, Backe B, Skjeldestad FE.
    Journal: Tidsskr Nor Laegeforen; 1999 Nov 10; 119(27):4019-21. PubMed ID: 10613090.
    Abstract:
    Medical termination of pregnancy in the second trimester is a painful and a time-consuming procedure. This study comprises 110 consecutive second trimester terminations of pregnancy performed 1994-96. In 76 women (69%) the procedure was a legal abortion due to foetal malformations, 25 women (23%) had an intrauterine foetal death, and in 9 (8%) cases pregnancy was terminated because of persisting drainage of amniotic fluid. All cases with intrauterine foetal death and early drainage of amniotic fluid were successfully treated after application of up to five vagitories of gemeprost (mean 2.8 vagitories; mean induction-abortion interval 8.9 hours). In patients undergoing abortion due to foetal malformations, the mean induction-abortion time was longer (mean 22.7 hours, mean 5.2 vagitories) and 20% did not respond adequately to prostaglandin. Our results show that gemeprost is an efficient means of terminating a pregnancy in cases of foetal death or pre-term amniorrhea, but that it is less efficient in inducing abortion.
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