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  • Title: Immunopathogenesis of Behçet's disease.
    Author: Lehner T.
    Journal: Ann Med Interne (Paris); 1999 Oct; 150(6):483-7. PubMed ID: 10615534.
    Abstract:
    A working hypothesis is postulated for the immunopathogenesis of Behçet's disease (BD). Microbial infection induced stress upregulates HSP65 and MICA gene product which stimulate gamma delta and alpha beta T cell receptor positive cells, to generate effector and suppressor T cells (fig. 1). These activated T cells, antibodies and neutrophils induce cytokines to modulate the immune response. The end result of these complex cellular and cytokine immune interactions in HLA-B51 or genetically related subjects is to induce pathological changes consistent with BD.
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