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  • Title: Synthesis and antiviral activity of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 3: Adenosine and uridine analogues.
    Author: Isabel Nieto M, Manuel Blanco J, Caamaño O, Fernández F, García-Mera X, López C, Balzarini J, De Clercq E.
    Journal: Nucleosides Nucleotides; 1999 Oct; 18(10):2253-63. PubMed ID: 10616729.
    Abstract:
    Six new carbocyclic nucleosides were prepared by mounting a purine (compounds 4-6), 8-azapurine (7 and 8) or uridine (9) base on the amino group of (1S,3R)-3-amino-2,2,3-trimethylcyclopentylmethanol (10). At subtoxic concentrations, compounds 5-9 showed at best marginal antiviral activity.
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