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  • Title: Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression.
    Author: Letsou GV, Safi HJ, Reardon MJ, Ergenoglu M, Li Z, Klonaris CN, Baldwin JC, Gilbert BE, Waldrep JC.
    Journal: Ann Thorac Surg; 1999 Dec; 68(6):2044-8. PubMed ID: 10616974.
    Abstract:
    BACKGROUND: The results of pulmonary transplantation are compromised by acute and chronic rejection. We hypothesized that a liposomal form of aerosolized cyclosporine A (CsA) would be selectively deposited and concentrated in the lungs. The theoretical advantage of this therapy is selective pulmonary immunosuppression with prolonged utilization. METHODS: Eighteen dogs were endotracheally intubated; aerosolized liposomal CsA was administered for 15 min. CsA levels were measured in whole blood, lung, trachea, heart, kidney, liver, and spleen at various times after treatment. RESULTS: The lung rapidly absorbs aerosolized liposomal CsA; other organs have much lower concentrations. The retention of pulmonary CsA delivered by liposome aerosol is approximately 120 min in this model. CONCLUSIONS: Aerosolized liposomal CsA is selectively deposited and concentrated in the lungs; other organs absorb less CsA.
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