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  • Title: Familial microscopic hematuria caused by hypercalciuria and hyperuricosuria.
    Author: Praga M, Alegre R, Hernández E, Morales E, Domínguez-Gil B, Carreño A, Andrés A.
    Journal: Am J Kidney Dis; 2000 Jan; 35(1):141-5. PubMed ID: 10620556.
    Abstract:
    We report 12 patients belonging to five different families in whom persistent isolated microhematuria was associated with hypercalciuria and/or hyperuricosuria. Four patients had episodes of gross hematuria, three patients had passed renal stones, and a history of nephrolithiasis was obtained in four of the families (80%). Calcium oxalate and uric acid crystals were commonly observed in the urine sediments. Urinary erythrocytes had a normal appearance on phase-microscopic examination. Reduction of calciuria and uricosuria by thiazide diuretics, allopurinol, forced fluid intake, and dietetic measures led to a persistent normalization of urine sediment with complete disappearance of hematuria. Determination of calcium and uric acid urinary excretions should be included in the study of familial hematuria.
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