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  • Title: The role of striatal adenosine A2A receptors in regulation of the muscle tone in rats.
    Author: Wardas J, Konieczny J, Lorenc-Koci E.
    Journal: Neurosci Lett; 1999 Dec 03; 276(2):79-82. PubMed ID: 10624796.
    Abstract:
    The aim of the present study was to assess contribution of striatal adenosine A2A receptors to regulation of the muscle tone in rats. The muscle tone was examined by a combined mechano- and electromyographic method, which measured simultaneously muscle resistance (MMG) of a rats hind foot to passive extension and flexion in the ankle joint and the electromyographic activity (EMG) of the antagonistic muscles: gastrocnemius and tibialis anterior. CGS 21680 (1 and 2 microg/0.5 microl), injected bilaterally into the rostral part of the striatum, dose-dependently increased both MMG and the EMG. The present results show that stimulation of striatal adenosine A2A receptors by CGS 21680 evokes parkinsonian-like muscle rigidity which may be due to activation of the GABAergic strio-pallidal pathway.
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