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  • Title: beta-Adrenergic receptor involvement in 6-hydroxydopamine-induced supersensitivity in rat cerebral cortex.
    Author: Sporn JR, Harden TK, Wolfe BB, Molinoff PB.
    Journal: Science; 1976 Nov 05; 194(4265):624-6. PubMed ID: 10626.
    Abstract:
    The intraventricular administration of 6-hydroxydopamine, a procedure which destroys noradrenergic nerve terminals in the central nervous system, caused an increase in the density of beta-adrenergic receptors in rat cerebral cortex, without affecting their affinity for isoproterenol. The results suggest that changes in the density of adrenergic receptors are involved in 6-hydroxydopamine-induced supersensitivity at central noradrenergic synapses.
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