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  • Title: CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS.
    Author: Becher B, Blain M, Antel JP.
    Journal: J Neuroimmunol; 2000 Jan 03; 102(1):44-50. PubMed ID: 10626665.
    Abstract:
    The APC-derived cytokine interleukin (IL)-12 polarizes CD4 T cells towards the pro-inflammatory Th1 phenotype and has been shown to be crucial for the development of EAE in rodents. In this study we demonstrate that production of IL-12 by human adult CNS-derived microglial cells can be triggered by cell contact with activated T cells. Microglial activation and IL-12 production can be blocked by anti-CD154 mAbs. IL-12 production could also be induced by direct engagement of CD40 on microglia using a CD40 agonist. IL-12 secretion by microglia is significantly reduced by TNF and IFN-gamma antagonists showing that the IL-12 production is subject to regulation by auto- and paracrine stimuli.
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