These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Heat-induced drug resistance is associated with increased expression of Bcl-2 in HL60.
    Author: Inoue Y, Sato Y, Nishimura M, Seguchi M, Zaitsu Y, Yamada K, Oka Y.
    Journal: Anticancer Res; 1999; 19(5B):3989-92. PubMed ID: 10628342.
    Abstract:
    HL60 cells underwent apoptosis with heat treatment, i.e. exposure to 42 degrees C for 120 minutes. Cells exposed to the same temperature for 30 minutes became resistant to subsequent, otherwise lethal, heat shock. These thermotolerant cells also acquired resistance to anti-cancer drugs including daunorubicin and VP16. We found that mild heat shock upregulates not only HSP70 but also BCL-2, though BCL-2 has not previously been recognized as a heat-inducible protein. Expression of BCL-2 closely paralleled resistance to subsequent exposure to anticancer drugs. The present results suggest that BCL-2 may play a role in heat-induced drug resistance.
    [Abstract] [Full Text] [Related] [New Search]