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  • Title: [Chronic adrenal insufficiency in childhood: clinical features and hormonal diagnosis (author's transl)].
    Author: Zimprich H.
    Journal: Wien Klin Wochenschr Suppl; 1975; 34():1-9. PubMed ID: 1062871.
    Abstract:
    An investigation was carried out on 6 children with clinical symptoms of adrenal insufficiency. The diagnosis was verified biochemically in 4 cases, 1 child was found to have secondary adrenal insufficiency and 1 had normal adrenal function. These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss. The clinical picture is correlated in extenso to the biochemical data in respect of ketosteroids, corticosteroids, plasma corticoids, cortisol secretion rate and aldosterone determination in a constant ACTH stimulation test. The methods of determination of the plasma aldosterone level and the cortisol secretion rate were greatly modified and redeveloped in this laboratory.
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