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  • Title: [Effectiveness of mesoglycan topical treatment of leg ulcers in subjects with chronic venous insufficiency].
    Author: La Marca G, Pumilia G, Martino A.
    Journal: Minerva Cardioangiol; 1999 Sep; 47(9):315-9. PubMed ID: 10630070.
    Abstract:
    BACKGROUND: Aim of the present comparative clinical study was to demonstrate the efficacy of the topical application of mesoglycan, a profibrinolytic agent, for healing of leg ulcers in patients with chronic venous insufficiency. METHODS: Forty patients, observed in our outpatients department, with venous leg ulcers have been randomized in two groups of twenty subjects, each treated with topical application of mesoglycan (1 or 2 vials/day) or vegetal stimulins and followed for two months, with controls after 15, 30 and 60 days. RESULTS: At the end of the observation period, ulcer healing rate was 95% in the mesoglycan group, while a lower healing rate was obtained in the stimulins group (80%). CONCLUSIONS: The present study confirms previous clinical experiences with mesoglycan and suggests its application in the topical treatment of venous ulcers.
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