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  • Title: Interaction of cations and chelators with the intestinal absorption of tetracycline.
    Author: Poiger H, Schlatter C.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1979 Jan; 306(1):89-92. PubMed ID: 106309.
    Abstract:
    The influence of certain compounds on intestinal absorption of tetracycline was tested, using two different in vivo techniques: a) Disappearence of the drug from perfused intestinal segments of the rabbit; b) Measuring urinary excretion in the rat after oral dosage. Ca2+ and Fe2+ ions both reduced the permeation rate of tetracycline by about 30%. In presence of Ca2+ and salicylate ions, leading to ion-pair formation with the antibiotic, intestinal uptake was significantly increased in comparison to experiments where only calcium was present. A more pronounced increase was observed with EDTA. Phosphate ions had different effects on the uptake of the antibiotic in both experimental techniques. Possible mechanisms are discussed.
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