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  • Title: Interleukin-4 mediates STAT6 activation in 3T3-L1 preadipocytes but not adipocytes.
    Author: Deng J, Hua K, Lesser SS, Greiner AH, Walter AW, Marrero MB, Harp JB.
    Journal: Biochem Biophys Res Commun; 2000 Jan 19; 267(2):516-20. PubMed ID: 10631093.
    Abstract:
    STAT6 is abundantly expressed in 3T3-L1 preadipocytes and adipocytes but activating ligands are not well defined. In this report, we provide evidence that interleukin 4 (IL-4) induced JAK2-mediated STAT6 tyrosine phosphorylation and DNA binding in 3T3-L1 preadipocytes but not in 3T3-L1 adipocytes. Loss of IL-4-mediated STAT6 tyrosine phosphorylation occurred 2 days after preadipocytes were induced to differentiate into adipocytes but when cells remained phenotypically preadipocytes. 3T3-L1 adipocytes were still responsive to IL-4 through tyrosine phosphorylation of other cellular proteins. We conclude that IL-4 signals through STAT6 in 3T3-L1 preadipocytes but not in 3T3-L1 adipocytes. This differentiation-dependent loss of STAT6 activation may be critical for distinct biological effects of IL-4 in 3T3-L1 preadipocytes and adipocytes.
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