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  • Title: Ribose 1,5-bisphosphate regulates rat kidney cortex phosphofructokinase.
    Author: Ozeki T, Mitsui Y, Sugiya H, Furuyama S.
    Journal: Comp Biochem Physiol B Biochem Mol Biol; 1999 Nov; 124(3):327-32. PubMed ID: 10631808.
    Abstract:
    Phosphofructokinase (EC 2.7.1.11) is a major enzyme of the glycolytic pathway, catalyzing the conversion of fructose 6-phosphate to fructose 1,6-bisphosphate. In this study, we demonstrated the effect of ribose 1,5-bisphosphate on phosphofructokinase purified from rat kidney cortex. Ribose 1,5-bisphosphate relieved the phosphofructokinase from ATP inhibition and increased the affinity for fructose 6-phosphate at nanomolar concentrations. These activating effects of ribose 1,5-bisphosphate were enhanced in the presence of AMP. Ribose 1,5-bisphosphate reduced the inhibition of the phosphofructokinase induced by citrate. These results suggest that ribose 1,5-bisphosphate is an activator of rat kidney cortex phosphofructokinase and synergistically regulates the enzyme activity with AMP.
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