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  • Title: Does the degree of penicillin susceptibility of Streptococcus pneumoniae affect the bactericidal activity of co-amoxiclav versus oral cephalosporins at physiological concentrations? An in vitro pharmacodynamic simulation.
    Author: Prieto J, Giménez MJ, Balcabao IP, Gómez-Lus ML, Aguilar L.
    Journal: J Chemother; 1999 Oct; 11(5):345-8. PubMed ID: 10632379.
    Abstract:
    An in vitro model simulating amoxicillin-clavulanic acid (co-amoxiclav) versus oral cephalosporin serum concentrations was used to explore activity over time against penicillin-susceptible and non-susceptible Streptococcus pneumoniae. Initial inoculum reduction > 4 log cfu/ml (>99.9%) was obtained with co-amoxiclav against both strains. Cefuroxime, cefpodoxime and cefaclor achieved a similar reduction against the susceptible strain, but no reduction against the non-susceptible strain.
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