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  • Title: Administration of transdermal estrogen without progestin increases the capacity of plasma and serum to stimulate prostacyclin production in human vascular endothelial cells.
    Author: Mikkola T, Viinikka L, Ylikorkala O.
    Journal: Fertil Steril; 2000 Jan; 73(1):72-4. PubMed ID: 10632415.
    Abstract:
    OBJECTIVE: To determine whether transdermal hormone replacement therapy modifies the ability of plasma or serum to regulate the synthesis of prostacyclin and that of endothelin-1 by cultured human umbilical vein endothelial cells. DESIGN: Prospective, randomized study. SETTING: Department of Obstetrics and Gynecology, Helsinki University Central Hospital. PATIENT(S): Thirteen postmenopausal women with climacteric symptoms. INTERVENTIONS: Transdermal 17beta-E2 (50 microg/d) continuously combined with norethisterone acetate, (250 microg/d) on days 15-28 of the treatment cycles for 6 months. MAIN OUTCOME MEASURE(S): Levels of prostacyclin's metabolite 6-keto-prostaglandin F1alpha and of endothelin-1 released by cultured human umbilical vein endothelial cells. RESULT(S): Plasma and serum during the E2-only phase of hormone replacement therapy enhanced prostacyclin production by 20% +/- 8% (mean +/- SEM) and 23% +/- 11%, respectively. Plasma or serum taken during the E2 + norethisterone acetate phase failed to affect prostacyclin production. Hormone replacement therapy induced no change in the capacity of plasma or serum to release endothelin-1. CONCLUSION(S): Transdermal hormone replacement therapy during the E2-only phase increased the capacity of plasma and serum to enhance production of vasoprotective prostacyclin in human vascular endothelial cells, without affecting production of endothelin-1. Addition of norethisterone acetate prevented this stimulation.
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