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  • Title: Oxidized lipoproteins in blood plasma: possible marker of atherosclerosis progression.
    Author: Moriel P, Okawabata FS, Abdalla DS.
    Journal: IUBMB Life; 1999 Oct; 48(4):413-7. PubMed ID: 10632571.
    Abstract:
    Oxidized lipoproteins and antioxidants were detected during the course of hypercholesterolemia development in cholesterol-fed rabbits. Lipid peroxides in blood plasma and very-low-, low-, and high-density lipoproteins (beta-VLDL, LDL, and HDL) were increased during the course of hypercholesterolemia. The content of phospholipid peroxides increased in beta-VLDL and LDL in parallel to that of cholesterol, whereas the amount of alpha-tocopherol was decreased either in lipoproteins or blood plasma. Ascorbate and urate concentrations were also decreased. Lipid peroxides were positively correlated with volume and area of atherosclerotic lesions, suggesting a relation between the concentrations of lipid peroxides in blood plasma and the progression of atheromatous lesions.
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