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  • Title: The effect of age on in vitro motility speed of slow myosin extracted from single rat soleus fibres.
    Author: Höök P, Li X, Sleep J, Hughes S, Larsson L.
    Journal: Acta Physiol Scand; 1999 Dec; 167(4):325-6. PubMed ID: 10632634.
    Abstract:
    The effect of age on the motor protein myosin was examined in a novel in vitro motility assay. Myosin was extracted from soleus fibres of young (3-6 month) and old (20-24 month) rats. All fibres expressed the type I myosin heavy chain (MyHC) and the slow isoforms of the myosin light chains (MyLCs). In vitro motility speed was significantly (P < 0.001) faster in the young adult (1.43 +/- 0.23 microm s-1) than in the aged group (1.27 +/- 0.23 microm s-1). The result indicates that the age-related decrease in contractile speed observed in slow fibres may be the effect of a change in the properties of myosin with age.
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