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  • Title: Transdermal selegiline in HIV-associated cognitive impairment: pilot, placebo-controlled study.
    Author: Sacktor N, Schifitto G, McDermott MP, Marder K, McArthur JC, Kieburtz K.
    Journal: Neurology; 2000 Jan 11; 54(1):233-5. PubMed ID: 10636157.
    Abstract:
    The authors conducted a pilot randomized, double-blind, placebo-controlled clinical trial of the transdermal administration of selegiline in HIV+ patients to obtain preliminary data to assess its safety, tolerability, and impact on HIV-associated cognitive impairment. Both selegiline and placebo were well tolerated with few adverse events. Improvements favoring the selegiline group were suggested on single tests of verbal memory and motor/psychomotor performance, warranting a larger study.
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