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  • Title: Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera.
    Author: Mosier DR, Siklós L, Appel SH.
    Journal: Neurology; 2000 Jan 11; 54(1):252-5. PubMed ID: 10636164.
    Abstract:
    In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.
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