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  • Title: Regulating actin-filament dynamics in vivo.
    Author: Chen H, Bernstein BW, Bamburg JR.
    Journal: Trends Biochem Sci; 2000 Jan; 25(1):19-23. PubMed ID: 10637608.
    Abstract:
    The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover.
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