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  • Title: How does Mycobacterium leprae target the peripheral nervous system?
    Author: Rambukkana A.
    Journal: Trends Microbiol; 2000 Jan; 8(1):23-8. PubMed ID: 10637640.
    Abstract:
    Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.
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