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  • Title: Non-quantal acetylcholine release is increased after nitric oxide synthase inhibition.
    Author: Mukhtarov MR, Vyskocil F, Urazaev AK, Nikolsky EE.
    Journal: Physiol Res; 1999; 48(4):315-7. PubMed ID: 10638684.
    Abstract:
    After anticholinesterase treatment, depolarization of the postsynaptic muscle membrane by about 5 mV develops due to non-quantally released acetylcholine from the motor nerve terminal and can be revealed as hyperpolarization by the addition of curare (H-effect). The H-effect increases significantly to 8.7 mV after inhibition of NO-synthase by L-nitroarginine methylester (L-NAME) whilst no changes in the amplitude and frequency of quantal miniature endplate potentials are observed.
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