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  • Title: Serum beta-glucuronidase activity in a population of ex-coalminers.
    Author: Cobben NA, Drent M, De Vries J, Wouters EF, Van Dieijen-Visser MP, Henderson RF.
    Journal: Clin Biochem; 1999 Nov; 32(8):659-64. PubMed ID: 10638950.
    Abstract:
    BACKGROUND: The aim of this study was to investigate whether BGD activity is of additional value in the assessment of pulmonary inflammation caused by coal dust exposure. DESIGN AND METHODS: Ex-coalminers were included in this study. Forty-eight healthy male subjects, without a relevant medical history, were used as controls. RESULTS: In ex-coalminers serum BGD activity was higher compared to the control group. Moreover, ex-coalminers with a normal chest radiograph and normal serum LDH demonstrated elevated serum BGD compared to the control group. However, no relation was found in the total group of ex-coalminers between serum BGD activity and pulmonary function parameters. CONCLUSIONS: Our study adds in vivo human evidence to the already existing animal data that BGD is a potential biomarker useful in monitoring pulmonary inflammation caused by coal dust exposure.
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