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  • Title: In vitro development of resistance to telithromycin (HMR 3647), four macrolides, clindamycin, and pristinamycin in Streptococcus pneumoniae.
    Author: Davies TA, Dewasse BE, Jacobs MR, Appelbaum PC.
    Journal: Antimicrob Agents Chemother; 2000 Feb; 44(2):414-7. PubMed ID: 10639373.
    Abstract:
    The ability of 50 sequential subcultures in subinhibitory concentrations of telithromycin (HMR 3647), azithromycin, clarithromycin, erythromycin A, roxithromycin, clindamycin, and pristinamycin to select for resistance was studied in five macrolide-susceptible and six macrolide-resistant pneumococci containing mefE or ermB. Telithromycin selected for resistance less often than the other drugs.
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