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  • Title: Inhibition of gastric secretion by exogenous secretin and cholecystokinin in normals and duodenal ulcer patients.
    Author: Jörgensen SP, Henriksen FW.
    Journal: Scand J Gastroenterol Suppl; 1976; 37():39-42. PubMed ID: 1064138.
    Abstract:
    The inhibitory effect of combined secretin (0.5 and 1.0 clin. unit/kg b.w./hour) and cholecystokinin (0.5 and 1.0 IDU/kg b.w./hour on the pentagastrin-stimulated (0.15--1.0 and 6.0 ug/kg b.w./hour) gastric secretion was investigated in twelve volunteers and in twelve duodenal ulcer patients. Regardless of the dose level no difference was found between normals and duodenal ulcer patients, indicating that a decreased sensitivity to secretin and cholecystokinin is not a pathogenetic factor for the development of duodenal ulcer.
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