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  • Title: Intravesicular instillation of E-aminocaproic acid for patients with adenovirus-induced hemorrhagic cystitis.
    Author: Lakhani A, Raptis A, Frame D, Simpson D, Berkahn L, Mellon-Reppen S, Klingemann H.
    Journal: Bone Marrow Transplant; 1999 Dec; 24(11):1259-60. PubMed ID: 10642819.
    Abstract:
    Hemorrhagic cystitis (HC) is a known complication of allogenic BMT. We report a case of a 28-year-old female with CML in chronic phase, which was treated with a matched unrelated donor (MUD) transplant, complicated by hemorrhagic cystitis on day +42 after the transplant. Adenovirus was isolated from the urine and she was treated with ribavirin, 1 g twice a day for 8 days. We report the use of Amicar (E-aminocaproic acid), 2.5 g solution as bladder instillation to treat the intractable hematuria.
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