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  • Title: Strain difference in amiloride-sensitivity of salt-induced responses in mouse non-dissociated taste cells.
    Author: Miyamoto T, Fujiyama R, Okada Y, Sato T.
    Journal: Neurosci Lett; 1999 Dec 17; 277(1):13-6. PubMed ID: 10643886.
    Abstract:
    The chorda tympani nerve responses to NaCl in a mouse strain, C57BL/6 are known to be much more sensitive than those in BALB/c. We compared the NaCl-induced responses obtained from taste cells of the fungiform papillae in these two strains of mice. Amiloride inhibited, in the same degree, the responses induced by a bath-application of normal extracellular solution (NES) containing 140 mM NaCl in either taste cells of C57BL/6 and BALB/c mice. In contrast, amiloride inhibited 62% of responses induced by an apically applied 0.5 M NaCl in the C57BL/6 strain, but only 33% of responses in the BALB/c strain. These results suggest that the difference in amiloride-sensitivity between taste cells in both strains mainly derives from the difference in density of functional amiloride sensitive Na+ channels at the apical receptive membrane but not at the basolateral membrane.
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