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  • Title: The effect of intrastriatal injection of liposome-entrapped tyrosinase on the dopamine levels in the rat brain.
    Author: Amicarelli F, Gasbarri A, Masciocco L, Pompili A, Pacitti C, Carlucci G, Palumbo G, Miranda M.
    Journal: Cell Mol Biol (Noisy-le-grand); 1999 Nov; 45(7):1093-7. PubMed ID: 10644014.
    Abstract:
    Parkinson's disease is a neurodegenerative disorder which is mainly characterized by degeneration of the dopaminergic cells in the nigro-striatal system. Due to a lowered L-tyrosine 3-monooxygenase activity, L-tyrosine is not sufficiently transformed to L-DOPA. To date the most common therapy is the administration of the dopamine precursor L-DOPA, with severe collateral effects. Therefore, the substitution of the lacking tyrosine hydroxylase with tyrosinase might be a novel therapeutical approach that would generate specifically L-DOPA from L-tyrosine. We present here evidence that stereotaxic injection of liposome-entrapped tyrosinase is able to significatively increase the levels of dopamine in the rat brain. The catecholamines L-DOPA, dopamine, L-epinephrine, L-norepinephrine were extracted by acid treatment from the brains and detected by HPLC.
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