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  • Title: Low-dose versus high-dose insulin therapy for diabetic ketoacidosis.
    Author: Pfeifer MA, Samols E, Wolter CF, Winkler CF.
    Journal: South Med J; 1979 Feb; 72(2):149-54. PubMed ID: 106476.
    Abstract:
    The effects of low-dose continuous insulin therapy were compared to those of high-dose subcutaneous and intravenous insulin therapy in six episodes of diabetic ketoacidosis. Time for correction of acidosis, ketosis, and hyperglycemia were similar for both regimens. The high-dose method required more exogenous glucose and supplemental potassium to avoid hypoglycemia and/or hypokalemia during treatment. Levels of cortisol, human growth hormone, and glucagon, initially elevated in most patients, showed a progressive decline with both modes of therapy. Plasma insulin remained remarkably stable during both treatment regimens, but remained within the physiologic range only in patients receiving low-dose therapy. Our study suggest that either modality is effective in the treatment of diabetic ketoacidosis.
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