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  • Title: Simultaneous detection of tyrosine hydroxylase-immunoreactivity and vasopressin mRNA in neurons of the human paraventricular and supraoptic nucleus.
    Author: Panayotacopoulou MT, Goudsmit E, Van Heerikhuize JJ, Swaab DF.
    Journal: Brain Res; 2000 Feb 07; 855(1):181-5. PubMed ID: 10650148.
    Abstract:
    Our purpose was to investigate the proportion of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons expressing vasopressin (VP) mRNA in the human paraventricular and supraoptic nuclei by combining in situ hybridization with immunohistochemistry on the same tissue section. A variability in the proportion of TH-IR neurons synthesizing VP mRNA was observed in adults which was usually more than 50%. In neonates almost all the TH-IR neurons appeared to contain VP mRNA.
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