These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The anxiolytic effect of ondansetron and its capacity to eliminate the benzodiazepine abstinence syndrome in rats].
    Author: Garibova TL, Voronina TA, Kraĭneva VA, Val'dman EA.
    Journal: Eksp Klin Farmakol; 1999; 62(6):16-9. PubMed ID: 10650519.
    Abstract:
    Ondansetron (GR38032F, zofran)--a specific blocker of 5-HT3-receptors in a dose range of 0.05 to 0. mg/kg causes an anxiolytic effect in experiments on mice and rats on a model of elevated plus maze. The drug does not produce a sedative and myorelaxant effect. A 0.05 mg/kg dose of ondansetron reduces the level of anxiety and convulsive manifestations which are induced by discontinuation of long-term diazepam administration. The results of the study bear evidence of selectivity of the anxiolytic effect of ondansetron in intact animals and its effectiveness in rats with diazepam abstinence.
    [Abstract] [Full Text] [Related] [New Search]