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  • Title: [The relationship of polymorphism of angiotensinogen and angiotensin converting enzyme with essential hypertension].
    Author: Ye Q, Wu K, Xie L, Zeng K, Lin J, Lin C.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2000 Feb; 17(1):28-31. PubMed ID: 10653905.
    Abstract:
    OBJECTIVE: In order to investigate the candidate genes for essential hypertension(EH), the authors determined the frequencies of M235T allele variation in exon 2 of angiotensinogen(AGT) gene and angiotensin converting enzyme (ACE) gene in 95 normotensives and 87 hypertensives in Chinese. METHODS: Polymerase chain reaction combined with restriction enzyme digestion was used to detect the variation AGT gene while PCR was used to determine ACE gene polymorphism. RESULTS: T235 allele frequency was significantly higher in hypertensive patients than in controls (0.45 vs 0.33, P<0. 05) and it was noticeably higher in male hypertensives. The frequency of ACE D allele in the EH patients with family history was higher than that in controls(0.59 vs 0.41,P<0.05). CONCLUSION: The variation of AGT gene was involved in the pathogenesis of hypertension, especially in male. The ACE D allele was associated with EH with family history.
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