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  • Title: The basal plasma histamine level and eosinophil count in allergic and non-allergic patients.
    Author: Kimura K, Adachi M, Kubo K, Ikemoto Y.
    Journal: Fukuoka Igaku Zasshi; 1999 Dec; 90(12):457-63. PubMed ID: 10655666.
    Abstract:
    OBJECTIVE: The basal plasma histamine level and eosinophil count in the peripheral blood in patients with a history of allergy (allergic patients) were examined and compared with those in patients without any history of allergy (non-allergic patients). SUBJECTS: We preoperatively examined 70 allergic patients and 70 non-allergic patients who were all scheduled to undergo oral surgery. METHODS: The basal plasma histamine level and eosinophil count in the peripheral blood were measured preoperatively. The high performance liquid chromatography (HPLC) post label system was used to measure the plasma histamine level. RESULTS: The mean basal plasma histamine level in non-allergic patients and allergic patients were 0.31 +/- 0.27 ng/ml and 0.47 +/- 0.30 ng/ml, respectively (p < 0.01). The mean eosinophil counts in non-allergic patients and allergic patients were 3.3 +/- 3.0% and 5.3 +/- 3.4%, respectively (p < 0.01). The patients who had asthma, atopic dermatitis or a food-induced allergy showed a high level of basal plasma histamine compared to that in non-allergic patients. The patients with asthma, allergic rhinitis or atopic dermatitis all demonstrated a higher eosinophil count than non-allergic patients. In addition, the correlation between the plasma histamine level and the eosinophil count was statistically significant (p < 0.05). CONCLUSIONS: The allergic patients had both higher basal plasma histamine levels and eosinophil counts than non-allergic patients (p < 0.01).
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