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  • Title: Chloramphenicol-a possible role in the treatment of leukaemia?
    Author: Schwarz MA, Firkin BG.
    Journal: Med J Aust; 1976 May 08; 1(19):687-90. PubMed ID: 1065792.
    Abstract:
    The effect of chloramphenicol in short term in-vitro bone marrow cultures was studied. There was a striking reduction in the incorporation of tritiated thymidine into DNA in bone marrow cultures with abnormal proliferative properties as compared with normal tissue. A 50% reduction in DNA thymidine incorporation in leukaemia marrow was also obtained with in-vitro chloramphenicol concentrations which in contrast had little or no effect in normal tissue. These in-vitro levels of the antibiotic can be readily achieved in vivo. An in-vivo study confirmed the ability of chloramphenicol to reduce the white cell and blast count in a patient with chronic myeloid leukaemia in blastic transformation.
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