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  • Title: Carnitine supplementation and ketogenesis by small-for-date neonates on medium-and long-chain fatty acid formulae.
    Author: Labadaridis J, Mavridou I, Sarafidou G, Alexiou N, Costalos C, Michelakakis H.
    Journal: Biol Neonate; 2000; 77(1):25-8. PubMed ID: 10658827.
    Abstract:
    Carnitine is a key molecule in energy production from various substrates. Although it is generally believed that it plays no role in the metabolism of medium-chain triglycerides, quite a few data exist to the contrary. In the present study we investigated the effect of carnitine on ketogenesis in small-for-date neonates fed formulae of equal caloric value and fat content that was predominantly long-chain triglycerides or medium-chain triglycerides (46% of total fat). According to our results there was a statistically significant interaction between carnitine and the chain length of the administered fat with respect to ketone production. Increased ketogenesis was only shown by the neonates receiving medium-chain triglycerides and carnitine. Our results provide further evidence for the involvement of carnitine in medium-chain triglyceride metabolism.
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