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  • Title: Anticandidal activity of SPA-S-843, a new polyenic drug.
    Author: Strippoli V, D'Auria FD, Simonetti G, Bruzzese T, Simonetti N.
    Journal: J Antimicrob Chemother; 2000 Feb; 45(2):235-7. PubMed ID: 10660508.
    Abstract:
    The activity of a new, soluble and stable polyene (SPA-S-843) against Candida albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lower MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida sp. conversion from yeast to mycelial form was evident at low drug concentrations (0.25-0.62 mg/L).
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