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  • Title: [Isolation of acyclovir-resistant strains of herpes simplex virus from clinical material].
    Author: L'vov ND, Andronova VL, Leont'eva NA, Galegov GA.
    Journal: Vopr Virusol; 1999; 44(6):247-9. PubMed ID: 10665057.
    Abstract:
    A total of 115 strains of herpes simplex virus were isolated from clinical material collected in patients with genital herpes. The majority (93%) of isolated strains were sensitive to acyclovir: ID50 varied from 0.15 to 0.80 microgram/ml acyclovir. Eleven (7%) strains from 4 patients were resistant to acyclovir: ID50 was 30-125 times higher in comparison with the reference HSV-1 strain L2.
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